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Ebola research highlights

Top left to right: © Sam Taylor/Ärzte ohne Grenzen / dpa, © narvikk / Getty Images / iStock Bottom: © Cynthia Goldsmith / CDCOn 17 July 2019, the Ebola virus disease outbreak in the Democratic Republic of the Congo was declared a Public Health Emergency of International Concern by the World Health Organization. Relevant research published from 2013 onwards in BMC and SpringerOpen journals is collected here for the convenience of researchers and healthcare workers.

We have also collected more Ebola-related articles and books from across Springer Nature here.

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  1. In the three decades since the first reported case of Ebola virus, most known index cases have been consistently traced to the hunting of “bush meat”, and women have consistently recorded relatively high fatal...

    Authors: Miriam N. Nkangu, Oluwasayo A. Olatunde and Sanni Yaya

    Citation: Infectious Diseases of Poverty 2017 6:135

    Content type: Scoping Review

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  2. During the 2013–2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA.

    Authors: Emanuele Nicastri, Antonio Brucato, Nicola Petrosillo, Gianluigi Biava, Timothy M. Uyeki and Giuseppe Ippolito

    Citation: BMC Infectious Diseases 2017 17:597

    Content type: Case report

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  3. Ebolaviruses have been known to cause deadly disease in humans for 40 years and have recently been demonstrated in West Africa to be able to cause large outbreaks. Four Ebolavirus species cause severe disease ass...

    Authors: Morena Pappalardo, Francesca Collu, James Macpherson, Martin Michaelis, Franca Fraternali and Mark N. Wass

    Citation: BMC Genomics 2017 18(Suppl 5):566

    Content type: Research

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    This article is part of a Supplement: Volume 18 Supplement 5

  4. Communication is of paramount importance in responding to health crises. We studied the media messages put forth by different stakeholders in two Ebola vaccine trials that became controversial in Ghana. These ...

    Authors: Per Egil Kummervold, William S. Schulz, Elizabeth Smout, Luis Fernandez-Luque and Heidi J. Larson

    Citation: BMC Public Health 2017 17:642

    Content type: Research article

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  5. Across low-income settings, community volunteers and health committee members support the formal health system - both routinely and amid emergencies - by engaging in health services such as referrals and healt...

    Authors: Shannon A. McMahon, Lara S. Ho, Kerry Scott, Hannah Brown, Laura Miller, Ruwan Ratnayake and Rashid Ansumana

    Citation: BMC Health Services Research 2017 17:495

    Content type: Research article

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  6. West Africa was the focus of global attention during the Ebola virus disease outbreak, when systemic health system weaknesses compounded a serious emergency and complicated response efforts. Following the cris...

    Authors: Sue Godt, Sharmila Mhatre and Anne-Marie Schryer-Roy

    Citation: Health Research Policy and Systems 2017 15(Suppl 1):52

    Content type: Introduction

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    This article is part of a Supplement: Volume 15 Supplement 1

  7. Between 2013 and 2016, West Africa experienced the largest ever outbreak of Ebola Virus Disease. In the absence of registered treatments or vaccines to control this lethal disease, the World Health Organizatio...

    Authors: Emilie Alirol, Annette C. Kuesel, Maria Magdalena Guraiib, Vânia de la Fuente-Núñez, Abha Saxena and Melba F. Gomes

    Citation: BMC Medical Ethics 2017 18:43

    Content type: Debate

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    The Erratum to this article has been published in BMC Medical Ethics 2017 18:45

  8. The recent Ebola Virus Disease (EVD) epidemic that hit some countries in West Africa underscores the need to train front line high-risk health workers on disease prevention skills. Although Ghana did not recor...

    Authors: Augustina Angelina Annan, Denis Dekugmen Yar, Michael Owusu, Eno Akua Biney, Paa Kobina Forson, Portia Boakye Okyere, Akosua Adumea Gyimah and Ellis Owusu-Dabo

    Citation: BMC Public Health 2017 17:546

    Content type: Research article

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  10. The outbreak of the Ebola virus disease (EVD) in West Africa in December 2013 was the largest Ebola outbreak in history. This study aimed to measure the underlying contextual and psychosocial factors of intent...

    Authors: Anna E. Gamma, Jurgita Slekiene, Gregor von Medeazza, Fredrik Asplund, Placido Cardoso and Hans-Joachim Mosler

    Citation: BMC Public Health 2017 17:446

    Content type: Research article

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  11. Rebuilding transformation strategies in post-Ebola epidemics in West Africa requires long-term surveillance and strengthening health system preparedness to disease outbreak. This paper assesses reconstruction ...

    Authors: Ernest Tambo, Chryseis F. Chengho, Chidiebere E. Ugwu, Isatta Wurie, Jeannetta K. Jonhson and Jeanne Y. Ngogang

    Citation: Infectious Diseases of Poverty 2017 6:71

    Content type: Letter to the Editor

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  12. Ebola virus (EBOV) infection results in high morbidity and mortality and is primarily transmitted in communities by contact with infectious bodily fluids. While clinical and experimental evidence indicates tha...

    Authors: Andrew D. Haddow, Farooq Nasar, Christopher W. Schellhase, Roger D. Moon, Susana L. Padilla, Xiankun Zeng, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Elizabeth C. Grimes, Justine M. Zelko, Kenneth J. Linthicum, Sina Bavari, M. Louise Pitt and John C. Trefry

    Citation: Parasites & Vectors 2017 10:218

    Content type: Short report

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  13. Since March 2014, the Ebola Virus Disease (EVD) outbreak in West Africa disrupted health care systems - especially in Guinea, Liberia and Sierra Leone – with a consequential stress on the area’s routine immuni...

    Authors: Xiaojin Sun, T. T. Samba, Jianyi Yao, Wenwu Yin, Lin Xiao, Fuqiang Liu, Xiaoqiang Liu, Jikun Zhou, Zengqiang Kou, Hongwei Fan, Hao Zhang, Aqnes Williams, Paul M. Lansana and Zundong Yin

    Citation: BMC Public Health 2017 17:363

    Content type: Research article

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  14. By the end of the 2013–2016 West African Ebola Virus Disease (EVD) outbreaks, a total of 3814 cases (probable and confirmed) and 2544 deaths were reported in Guinea. Clearly, surveillance activities aiming at ...

    Authors: Mory Keïta, Fatoumata Conté, Boubacar Diallo, Dieudonné Lufwa, Jacques Katomba, René Snacken, Raymond Pallawo, Aminata Tolno, Amadou Bailo Diallo, Mamadou Harouna Djingarey and Lorenzo Subissi

    Citation: BMC Infectious Diseases 2017 17:304

    Content type: Case report

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  15. Ebola virus is highly infectious and the disease can be very fatal. The World Health Organization has declared the 2014–2015 Ebola Virus Disease outbreak a Public Health Emergency of International Concern. In ...

    Authors: Philip Baba Adongo, Philip Teg-Nefaah Tabong, Emmanuel Asampong, Joana Ansong, Magda Robalo and Richard M. Adanu

    Citation: BMC Health Services Research 2017 17:266

    Content type: Research article

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  16. The 2013–2016 West African Ebola outbreak infected 28,616 people and caused 11,310 deaths by 11 May 2016, across six countries. The outbreak has also resulted in the largest number of EVD survivors in history—...

    Authors: Mamady Mory Keita, Bernard Taverne, Sékou Sy Savané, Laura March, Morifodé Doukoure, Mamadou Saliou Sow, Abdoulaye Touré, Jean François Etard, Moumié Barry and Eric Delaporte

    Citation: BMC Psychiatry 2017 17:127

    Content type: Research article

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  17. We report 4 cases of Health Workers (HW) suspected of having contracted Ebola Virus Disease (EVD), transported from the Alliance for International Medical Action (ALIMA) Ebola Treatment Centre (ETC) in N’Zerek...

    Authors: Jean-Michel Dindart, Olivier Peyrouset, Romain Palich, Abdoul Bing, Richard Kojan, Solenne Barbe, Souley Harouna and Nikki Blackwell

    Citation: BMC Emergency Medicine 2017 17:9

    Content type: Correspondence

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  18. The unprecedented impact and modeling efforts associated with the 2014–2015 Ebola epidemic in West Africa provides a unique opportunity to document the performances and caveats of forecasting approaches used i...

    Authors: Gerardo Chowell, Cécile Viboud, Lone Simonsen, Stefano Merler and Alessandro Vespignani

    Citation: BMC Medicine 2017 15:42

    Content type: Opinion

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  20. In the course of the Ebola outbreak in West Africa that was witnessed since early 2014, the response mechanisms showed deficits in terms of timeliness, volume and adequacy. The authors were deployed in the Ebo...

    Authors: Christian Janke, Katrin Moira Heim, Florian Steiner, Moses Massaquoi, Miatta Zenabu Gbanya, Claudia Frey and Guenter Froeschl

    Citation: BMC Infectious Diseases 2017 17:124

    Content type: Correspondence

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  21. In Bo district, rural Sierra Leone, we assessed the burden of the 2014 Ebola outbreak on under-five consultations at a primary health center and the quality of care for under-15 children at a Médecins Sans Fro...

    Authors: Veerle Hermans, Rony Zachariah, Desalegn Woldeyohannes, Gbessay Saffa, Dauda Kamara, Nimer Ortuno-Gutierrez, Walter Kizito, Marcel Manzi, Petra Alders and Jacob Maikere

    Citation: BMC Pediatrics 2017 17:34

    Content type: Research article

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  22. Amidst an Ebola virus disease (EVD) epidemic of unprecedented magnitude in west Africa, concerns about the risk of importing EVD led to the introduction of programs for the screening and monitoring of travelle...

    Authors: Jocelyn Chan, Mahomed Patel, Sean Tobin and Vicky Sheppeard

    Citation: BMC Public Health 2017 17:113

    Content type: Research article

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  23. In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatme...

    Authors: Xuan Liu, Emily Speranza, César Muñoz-Fontela, Sam Haldenby, Natasha Y. Rickett, Isabel Garcia-Dorival, Yongxiang Fang, Yper Hall, Elsa-Gayle Zekeng, Anja Lüdtke, Dong Xia, Romy Kerber, Ralf Krumkamp, Sophie Duraffour, Daouda Sissoko, John Kenny…

    Citation: Genome Biology 2017 18:4

    Content type: Research

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  24. Trained community health workers (CHW) enhance access to essential primary health care services in contexts where the health system lacks capacity to adequately deliver them. In Liberia, the Ebola outbreak fur...

    Authors: Kendra Siekmans, Salim Sohani, Tamba Boima, Florence Koffa, Luay Basil and Saïd Laaziz

    Citation: BMC Public Health 2017 17:84

    Content type: Research article

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  25. An Ebola outbreak started in December 2013 in Guinea and spread to Liberia and Sierra Leone in 2014. The health systems in place in the three countries lacked the infrastructure and the preparation to respond ...

    Authors: Haitham Shoman, Emilie Karafillakis and Salman Rawaf

    Citation: Globalization and Health 2017 13:1

    Content type: Review

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  26. Ebola and Marburg virus diseases are said to occur at a low prevalence, but are very severe diseases with high lethalities. The fatality rates reported in different outbreaks ranged from 24–100%. In addition, ...

    Authors: Luke Nyakarahuka, Clovice Kankya, Randi Krontveit, Benjamin Mayer, Frank N. Mwiine, Julius Lutwama and Eystein Skjerve

    Citation: BMC Infectious Diseases 2016 16:708

    Content type: Research article

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  29. During December 2014–February 2015, an Ebola outbreak in a village in Kono district, Sierra Leone, began following unsafe funeral practices after the death of a person later confirmed to be infected with Ebola...

    Authors: Tasha Stehling-Ariza, Alexander Rosewell, Sahr A. Moiba, Brima Berthalomew Yorpie, Kai David Ndomaina, Kai Samuel Jimissa, Eva Leidman, Dingeman J. Rijken, Colin Basler, James Wood and Dumbuya Manso

    Citation: BMC Infectious Diseases 2016 16:611

    Content type: Research article

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  30. As emergency response to the Ebola epidemic, the Government of Sierra Leone and its partners implemented a large-scale Mass Drug Administration (MDA) with artesunate–amodiaquine (ASAQ) covering >2.7 million pe...

    Authors: Maru Aregawi, Samuel J. Smith, Musa Sillah-Kanu, John Seppeh, Anitta R. Y. Kamara, Ryan O. Williams, John J. Aponte, Andrea Bosman and Pedro Alonso

    Citation: Malaria Journal 2016 15:480

    Content type: Research

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  31. Near the end of 2013, an outbreak of Zaire ebolavirus (EBOV) began in Guinea, subsequently spreading to neighboring Liberia and Sierra Leone. As this epidemic grew, important public health questions emerged about...

    Authors: Jolie Kaner and Sarah Schaack

    Citation: Globalization and Health 2016 12:53

    Content type: Review

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  32. Among the three countries most affected by the Ebola virus disease outbreak in 2014–2015, Guinea presents an unusual spatiotemporal epidemic pattern, with several waves and a long tail in the decay of the epid...

    Authors: Marco Ajelli, Stefano Merler, Laura Fumanelli, Ana Pastore y Piontti, Natalie E. Dean, Ira M. Longini Jr., M. Elizabeth Halloran and Alessandro Vespignani

    Citation: BMC Medicine 2016 14:130

    Content type: Research article

    Published on:

  33. Ebola virus is the causative agent of a severe syndrome in humans with a fatality rate that can approach 90 %. During infection, the host immune response is thought to become dysregulated, but the mechanisms t...

    Authors: Ignacio S. Caballero, Anna N. Honko, Stephen K. Gire, Sarah M. Winnicki, Marta Melé, Chiara Gerhardinger, Aaron E. Lin, John L. Rinn, Pardis C. Sabeti, Lisa E. Hensley and John H. Connor

    Citation: BMC Genomics 2016 17:707

    Content type: Research article

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  34. Ebola virus like particles (EBOV VLPs, eVLPs), are produced by expressing the viral transmembrane glycoprotein (GP) and structural matrix protein VP40 in mammalian cells. When expressed, these proteins self-a...

    Authors: Lisa H. Cazares, Michael D. Ward, Ernst E. Brueggemann, Tara Kenny, Paul Demond, Christopher R. Mahone, Karen A. O. Martins, Jonathan E. Nuss, Trevor Glaros and Sina Bavari

    Citation: Clinical Proteomics 2016 13:18

    Content type: Research

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  35. Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes high fever, rash, and recurrent arthritis in humans. It has efficiently adapted to Aedes albopictus, which also inhabits temperate region...

    Authors: Lisa Henß, Simon Beck, Tatjana Weidner, Nadine Biedenkopf, Katja Sliva, Christopher Weber, Stephan Becker and Barbara S. Schnierle

    Citation: Virology Journal 2016 13:149

    Content type: Research

    Published on:

  37. As of 20 May 2016 there have been 28,646 cases and 11,323 deaths resulting from the West African Ebola virus disease (EVD) outbreak reported to the World Health Organization. There continue to be sporadic flar...

    Authors: Aleksandra Leligdowicz, William A. Fischer II, Timothy M. Uyeki, Thomas E. Fletcher, Neill K. J. Adhikari, Gina Portella, Francois Lamontagne, Christophe Clement, Shevin T. Jacob, Lewis Rubinson, Abel Vanderschuren, Jan Hajek, Srinivas Murthy, Mauricio Ferri, Ian Crozier, Elhadj Ibrahima…

    Citation: Critical Care 2016 20:217

    Content type: Review

    Published on:

  38. Policy dialogue can be defined as an iterative process that involves a broad range of stakeholders discussing a particular issue with a concrete purpose in mind. Policy dialogue in health is increasingly being...

    Authors: Nadege Ade, Adzodo Réne, Mara Khalifa, Kevin Ousman Babila, Martin Ekeke Monono, Elongo Tarcisse and Juliet Nabyonga-Orem

    Citation: BMC Health Services Research 2016 16(Suppl 4):220

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 16 Supplement 4

  40. The last ebola virus disease (EVD) outbreak has been the most important since 1976. EVD cases decreased drastically in Sierra Leone at the beginning of 2015. We aim to determine the clinical findings and evolu...

    Authors: Javier Arranz, Karen Marie Lundeby, Shoaib Hassan, Luis Matías Zabala Fuentes, Pedro San José Garcés, Yngvar Lunde Haaskjold, Håkon Angell Bolkan, Kurt Østhuus Krogh, James Jongopi, Sindre Mellesmo, Ola Jøsendal, Åsmund Øpstad, Erling Svensen, Alfred Sandy Kamara, David P. Roberts, Paul D. Stamper…

    Citation: BMC Infectious Diseases 2016 16:308

    Content type: Research article

    Published on:

  41. Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is commo...

    Authors: Sabue Mulangu, Matthias Borchert, Janusz Paweska, Antoine Tshomba, Afongenda Afounde, Amayo Kulidri, Robert Swanepoel, Jean-Jacques Muyembe-Tamfum and Patrick Van der Stuyft

    Citation: BMC Infectious Diseases 2016 16:263

    Content type: Research article

    Published on:

  43. The recent outbreak of Ebola has been cited as the largest in history. Despite this global health crisis, few drugs are available to efficiently treat Ebola infections. Drug repurposing provides a potentially ...

    Authors: Zheng Zhao, Che Martin, Raymond Fan, Philip E. Bourne and Lei Xie

    Citation: BMC Bioinformatics 2016 17:90

    Content type: Research article

    Published on:

  44. The Ebola virus is highly pathogenic and destructive to humans and other primates. The Ebola virus encodes viral protein 40 (VP40), which is highly expressed and regulates the assembly and release of viral par...

    Authors: V. Karthick, N. Nagasundaram, C. George Priya Doss, Chiranjib Chakraborty, R. Siva, Aiping Lu, Ge Zhang and Hailong Zhu

    Citation: Infectious Diseases of Poverty 2016 5:12

    Content type: Research article

    Published on:

  45. The Ebola epidemic exposed the weak state of health systems in West Africa and their devastating effect on frontline health workers and the health of populations. Fortunately, recent reviews of mobile technolo...

    Authors: Akaninyene Otu, Bassey Ebenso, Okey Okuzu and Egbe Osifo-Dawodu

    Citation: Human Resources for Health 2016 14:5

    Content type: Research

    Published on:

  46. The global interest in developing therapies for Ebola infection management and its prevention is laudable. However the plan to conduct an emergency immunization program specifically for healthcare workers usin...

    Authors: Morenike Oluwatoyin Folayan, Aminu Yakubu, Bridget Haire and Kristin Peterson

    Citation: BMC Medical Ethics 2016 17:10

    Content type: Debate

    Published on:

  48. The production of recombinant monoclonal antibodies in mammalian cell culture is of high priority in research and medical fields. A critical step in this process is the isolation of the antigen-binding domain ...

    Authors: Gaily Kivi, Kaupo Teesalu, Jüri Parik, Elen Kontkar, Mart Ustav Jr, Liis Noodla, Mart Ustav and Andres Männik

    Citation: BMC Biotechnology 2016 16:2

    Content type: Methodology article

    Published on:

  49. Prior to the 2014–2015 Ebola outbreak, infection prevention and control (IPC) activities in Liberian healthcare facilities were basic. There was no national IPC guidance, nor dedicated staff at any level of go...

    Authors: Catherine Cooper, Dale Fisher, Neil Gupta, Rose MaCauley and Carmem L. Pessoa-Silva

    Citation: BMC Medicine 2016 14:2

    Content type: Commentary

    Published on:

  50. The West-African (WA) Zaire Ebolavirus disease (EVD) outbreak was characterized by an exceptionally high number of cases and deaths as compared with the Eastern-Central African (ECA) outbreaks. Despite the Zai...

    Authors: Stefano Petti, Giuseppe Alessio Messano, Enzo Maria Vingolo, Luigi Tonino Marsella and Crispian Scully

    Citation: BMC Infectious Diseases 2015 15:564

    Content type: Research article

    Published on: