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Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR. 

Page 2 of 6

  1. Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3’ends, thus greatly expanding the diversity of mRNAs and of proteins derived from a singl...

    Authors: Yi Zhang, Lian Liu, Qiongzi Qiu, Qing Zhou, Jinwang Ding, Yan Lu and Pengyuan Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:51

    Content type: Review

    Published on:

  2. Recent scientific advances have greatly enhanced our understanding of the complex link between the gut microbiome and cancer. Gut dysbiosis is an imbalance between commensal and pathogenic bacteria and the pro...

    Authors: Yanshan Ge, Xinhui Wang, Yali Guo, Junting Yan, Aliya Abuduwaili, Kasimujiang Aximujiang, Jie Yan and Minghua Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:42

    Content type: Review

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  3. The stimulator of interferon genes (STING) connects microbial cytosolic sensing with host cell effector functions. STING signaling plays a central role in cyclic dinucleotides (CDNs) and DNA sensing to induce ...

    Authors: Qiongyuan Hu, Quan Zhou, Xuefeng Xia, Lihua Shao, Meng Wang, Xiaofeng Lu, Song Liu and Wenxian Guan

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:39

    Content type: Review

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  4. Head and neck squamous cell carcinoma (HNSCC) is one of the main malignant tumours affecting human health, mainly due to delayed diagnosis and high invasiveness. Extracellular vehicles (EVs) are membranous ves...

    Authors: Xueying Wang, Junnan Guo, Pingyang Yu, Lunhua Guo, Xionghui Mao, Junrong Wang, Susheng Miao and Ji Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:35

    Content type: Review

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  5. Solid tumors often grow in a micro-environment characterized by < 2% O2 tension. This condition, together with the aberrant activation of specific oncogenic patwhays, increases the amount and activity of the hypo...

    Authors: Muhlis Akman, Dimas Carolina Belisario, Iris Chiara Salaroglio, Joanna Kopecka, Massimo Donadelli, Enrico De Smaele and Chiara Riganti

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:28

    Content type: Review

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  6. The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progressi...

    Authors: Piera Tocci, Giovanni Blandino and Anna Bagnato

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:27

    Content type: Review

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  7. With the success of immune checkpoint inhibitors (ICIs), significant progress has been made in the field of cancer immunotherapy. Despite the long-lasting outcomes in responders, the majority of patients with ...

    Authors: Bin Wang, Qin Zhao, Yuyu Zhang, Zijing Liu, Zhuangzhuang Zheng, Shiyu Liu, Lingbin Meng, Ying Xin and Xin Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:24

    Content type: Review

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  8. Endocrine therapies with SERMs (selective estrogen receptor modulators) or SERDs (selective estrogen receptor downregulators) are standard therapies for patients with estrogen receptor (ER)-positive breast can...

    Authors: Huanhuan Huang, Jun Zhou, Hailong Chen, Jiaxin Li, Chao Zhang, Xia Jiang and Chao Ni

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:19

    Content type: Review

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  9. AS (alternative splicing) is a fundamental process by which a gene can generate multiple distinct mRNA transcripts to increase protein diversity. Defects in AS influence the occurrence and development of many ...

    Authors: Yunze Liu, Xin Liu, Changwei Lin, Xianhong Jia, Hongmei Zhu, Jun Song and Yi Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:11

    Content type: Review

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  10. Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal malignancy, with an average 5-year survival rate of 9% (Siegel RL, Miller KD, Jemal A. Ca Cancer J Clin. 2019;69(1):7-34). The steady increase in ...

    Authors: Yiqi Yu, Gang Yang, Hua Huang, Ziyao Fu, Zhe Cao, Lianfang Zheng, Lei You and Taiping Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:8

    Content type: Review

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  11. The enthusiasm for immune checkpoint inhibitors (ICIs), an efficient tumor treatment model different from traditional treatment, is based on their unprecedented antitumor effect, but the occurrence of immune-r...

    Authors: Xiao-Hui Jia, Lu-Ying Geng, Pan-Pan Jiang, Hong Xu, Ke-Jun Nan, Yu Yao, Li-Li Jiang, Hong Sun, Tian-Jie Qin and Hui Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:284

    Content type: Review

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  12. Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during development, differentiation and maintenance of tissue hom...

    Authors: Anna Di Matteo, Elisa Belloni, Davide Pradella, Ambra Cappelletto, Nina Volf, Serena Zacchigna and Claudia Ghigna

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:275

    Content type: Review

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  13. An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes, including proliferation, apoptosis, migration, invasion, chromatin remodeling, ...

    Authors: Le Zhang, Cuixia Li and Xiulan Su

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:271

    Content type: Review

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  14. Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary way energy is produced to maintain...

    Authors: Lidong Cao, Jiacheng Wu, Xianzhi Qu, Jiyao Sheng, Mengying Cui, Shui Liu, Xu Huang, Yien Xiang, Bingjin Li, Xuewen Zhang and Ranji Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:267

    Content type: Review

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  15. Dendritic cells (DCs) secrete vast quantities of exosomes termed as dexosomes. Dexosomes are symmetric nanoscale heat-stable vesicles that consist of a lipid bilayer displaying a characteristic series of lipid...

    Authors: Sepideh Nikfarjam, Jafar Rezaie, Fatah Kashanchi and Reza Jafari

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:258

    Content type: Review

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  16. Gliomas, especially glioblastomas, represent one of the most aggressive and difficult-to-treat human brain tumors. In the last few decades, clinical immunotherapy has been developed and has provided exceptiona...

    Authors: Yuanliang Yan, Shuangshuang Zeng, Zhicheng Gong and Zhijie Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:257

    Content type: Review

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  17. Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different types of tumors, leading to improvement in survival, even in patients with advanced cancers. Despite the good clinical...

    Authors: Simone Camelliti, Valentino Le Noci, Francesca Bianchi, Claudia Moscheni, Francesca Arnaboldi, Nicoletta Gagliano, Andrea Balsari, Marina Chiara Garassino, Elda Tagliabue, Lucia Sfondrini and Michele Sommariva

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:236

    Content type: Review

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  18. Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs particip...

    Authors: Yalu Zhang, Qiaofei Liu and Quan Liao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:231

    Content type: Review

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  19. Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases.

    Authors: Claudio Luchini, Gaetano Paolino, Paola Mattiolo, Maria L. Piredda, Alessandro Cavaliere, Marina Gaule, Davide Melisi, Roberto Salvia, Giuseppe Malleo, Jae Il Shin, Sarah Cargnin, Salvatore Terrazzino, Rita T. Lawlor, Michele Milella and Aldo Scarpa

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:227

    Content type: Review

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  20. Hypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normo...

    Authors: Tiansheng Li, Chao Mao, Xiang Wang, Ying Shi and Yongguang Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:224

    Content type: Review

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  21. Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse...

    Authors: Xiang Gu, Jie Yu, Peiwei Chai, Shengfang Ge and Xianqun Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:215

    Content type: Review

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  22. Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy d...

    Authors: Claudio Pulito, Antonio Cristaudo, Caterina La Porta, Stefano Zapperi, Giovanni Blandino, Aldo Morrone and Sabrina Strano

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:210

    Content type: Review

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  23. High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal prognosis with a median survival of le...

    Authors: Faiqa Mudassar, Han Shen, Geraldine O’Neill and Eric Hau

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:208

    Content type: Review

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  24. Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor ce...

    Authors: Xianjie Jiang, Jie Wang, Xiangying Deng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Ke Cao, Hao Deng, Yi He, Qianjin Liao, Bo Xiang, Ming Zhou, Can Guo, Zhaoyang Zeng, Guiyuan Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:204

    Content type: Review

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  25. Advanced colorectal adenocarcinoma (CRAC), featured by distinctive histopathological appearance, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a group of heterogeneous cancers...

    Authors: Hang-Ping Yao, Xiang-Min Tong, Rachel Hudson and Ming-Hai Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:198

    Content type: Review

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  26. The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the mo...

    Authors: Yuhao Zhang, Xiuchao Geng, Qiang Li, Jianglong Xu, Yanli Tan, Menglin Xiao, Jia Song, Fulin Liu, Chuan Fang and Hong Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:192

    Content type: Review

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  27. Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)...

    Authors: Alberto Ocaña and Atanasio Pandiella

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:189

    Content type: Review

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  28. Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t...

    Authors: Yilan Yang, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Xiaomao Guo and Xiaoli Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:188

    Content type: Review

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  29. Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modif...

    Authors: Shanshan Zhao, Xue Zhang, Shuo Chen and Song Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:187

    Content type: Review

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  30. Molecular oxygen (O2) is a universal electron acceptor that is eventually synthesized into ATP in the mitochondrial respiratory chain of all metazoans. Therefore, hypoxia biology has become an organizational prin...

    Authors: Mingyao Huang, Liang Yang, Xueqiang Peng, Shibo Wei, Qing Fan, Shuo Yang, Xinyu Li, Bowen Li, Hongyuan Jin, Bo Wu, Jingang Liu and Hangyu Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:185

    Content type: Review

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  31. The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant gene...

    Authors: Andrew Brennan, James T. Leech, Neil M. Kad and Jody M. Mason

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:184

    Content type: Review

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  32. Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improv...

    Authors: Juncheng Cui, Dylan Dean, Francis J. Hornicek, Zhiwei Chen and Zhenfeng Duan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:178

    Content type: Review

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  33. A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance ...

    Authors: Cheng Yang, Jiayu Zhang, Yukui Ma, Chunfu Wu, Wei Cui and Lihui Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:173

    Content type: Review

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  34. As metastasis is a major cause of death in cancer patients, new anti-metastatic strategies are needed to improve cancer therapy outcomes. Numerous pathways have been shown to contribute to migration and invasi...

    Authors: Madiha Kanwal, Michal Smahel, Mark Olsen, Jana Smahelova and Ruth Tachezy

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:163

    Content type: Review

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  35. Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metas...

    Authors: Yue Ning, Hongmei Zheng, Yuting Zhan, Sile Liu, Yang yang, Hongjing Zang, Jiadi Luo, Qiuyuan Wen and Songqing Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:162

    Content type: Review

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  36. Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis and recurrence rate, and adipocytes are the largest components in breast tissue. The aberrant adipocytes, especially the...

    Authors: Chongru Zhao, Min Wu, Ning Zeng, Mingchen Xiong, Weijie Hu, Wenchang Lv, Yi Yi, Qi Zhang and Yiping Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:156

    Content type: Review

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  37. The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant ph...

    Authors: Rui Chen, Mengxian Zhang, Yangmei Zhou, Wenjing Guo, Ming Yi, Ziyan Zhang, Yanpeng Ding and Yali Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:138

    Content type: Review

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  38. Radiotherapy is the cornerstone of treatment of high-grade gliomas (HGGs). It eradicates tumor cells by inducing oxidative stress and subsequent DNA damage. Unfortunately, almost all HGGs recur locally within ...

    Authors: Han Shen, Kristina Cook, Harriet E. Gee and Eric Hau

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:129

    Content type: Review

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  39. Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sora...

    Authors: Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai and Chuanyong Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:126

    Content type: Review

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  40. The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic interventio...

    Authors: Katia Grillone, Caterina Riillo, Francesca Scionti, Roberta Rocca, Giuseppe Tradigo, Pietro Hiram Guzzi, Stefano Alcaro, Maria Teresa Di Martino, Pierosandro Tagliaferri and Pierfrancesco Tassone

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:117

    Content type: Review

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  42. Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of hypoxia-induced alternative splicing and how it influences ...

    Authors: Antonietta Rosella Farina, Lucia Cappabianca, Michela Sebastiano, Veronica Zelli, Stefano Guadagni and Andrew Reay Mackay

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:110

    Content type: Review

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  43. Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent stem cells and reprogrammed stem cells. One of the m...

    Authors: Kenly Wuputra, Chia-Chen Ku, Deng-Chyang Wu, Ying-Chu Lin, Shigeo Saito and Kazunari K. Yokoyama

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:100

    Content type: Review

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  44. Hepatocellular carcinoma (HCC) is one of the most common malignancies today. Patients suffer from HCC since its high malignancy and limited treatment means. With the development of genetic research, new therap...

    Authors: Xiaoling Wu, Weijie Ma, Chengjie Mei, Xi Chen, Ye Yao, Yingyi Liu, Xian Qin and Yufeng Yuan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:97

    Content type: Review

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  45. In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly presen...

    Authors: Marco Russano, Andrea Napolitano, Giulia Ribelli, Michele Iuliani, Sonia Simonetti, Fabrizio Citarella, Francesco Pantano, Emanuela Dell’Aquila, Cecilia Anesi, Nicola Silvestris, Antonella Argentiero, Antonio Giovanni Solimando, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:95

    Content type: Review

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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:120

  46. Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive ...

    Authors: Filippo Galli, Jesus Vera Aguilera, Belinda Palermo, Svetomir N. Markovic, Paola Nisticò and Alberto Signore

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:89

    Content type: Review

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  47. The very limited time allowed to face the COVID-19 pandemic poses a pressing challenge to find proper therapeutic approaches. However, synthesis and full investigation from preclinical studies to phase III tri...

    Authors: Gennaro Ciliberto, Rita Mancini and Marco G. Paggi

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:86

    Content type: Review

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  48. The majority of high-risk neuroblastomas can be divided into three distinct molecular subgroups defined by the presence of MYCN amplification, upstream TERT rearrangements or alternative lengthening of telomeres ...

    Authors: S. L. George, V. Parmar, F. Lorenzi, L. V. Marshall, Y. Jamin, E. Poon, P. Angelini and L. Chesler

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:78

    Content type: Review

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  49. The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which mod...

    Authors: Somshuvra Bhattacharya, Kristin Calar and Pilar de la Puente

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:75

    Content type: Review

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  50. Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as e...

    Authors: Shiming Tan, Longzheng Xia, Pin Yi, Yaqian Han, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Linda Oyang, Jiaxin Liang, Jinguan Lin, Min Su, Yingrui Shi, Deliang Cao, Yujuan Zhou and Qianjin Liao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:67

    Content type: Review

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