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Current Evidence and Future Directions in the Treatment of Colorectal Cancer

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By Anpol42 (Own work) [CC BY-SA 4.0], via Wikimedia Commons

Guest Editors:  Nicola Avenia, Roberto Cirocchi and Georgi Popivanov  

Management of colorectal cancers have undergone a sea change. Surgery still remains the mainstay of the treatment, however this too has evolved considerably since the introduction of laparoscopic surgery, 3D surgery, and robotics surgery. However, it is the chemotherapy that has made a significant impact on survival of these patients by controlling metastatic spread in colon cancer. The scene is slowly shifting to tailored treatment, depending on presence of various biomarkers and mutations. On the other hand, sphincter preservation has been made possible lowering rectal cancers by introduction of preoperative radiotherapy. These developments have not only increased the survival but also the quality of life of survivors.

In this thematic series, relevant articles are invited on colorectal cancer. The articles must relate to current and future trends in treatment of colorectal cancer. Surgical innovations, laparoscopic and robotic surgery, radiotherapy, chemotherapy, tumor targeting and tailoring therapy for colorectal cancer will be considered.

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  1. To assess the feasibility and short-term outcomes of neoadjuvant chemoradiotherapy (CCRT) followed by transanal total mesorectal excision assisted by single-port laparoscopic surgery (TaTME-SPLS) for low-lying...

    Authors: Yen-Jung Lu, Chien-Hsin Chen, En-Kwang Lin and Szu-Yuan Wu

    Citation: World Journal of Surgical Oncology 2020 18:198

    Content type: Research

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  2. Colorectal cancer resection surgery with transvaginal specimen extraction is becoming increasingly accepted and used by surgeons. However, few publications on robotic anterior sigmoid colon and rectal cancer r...

    Authors: Gengmei Gao, Lan Chen, Rui Luo, Bo Tang and Taiyuan Li

    Citation: World Journal of Surgical Oncology 2020 18:190

    Content type: Research

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  3. To evaluate the feasibility and safety of a new surgical method, complete laparoscopic extended right hemicolectomy with preservation of the ileocecal junction in right-transverse colon cancer.

    Authors: Hao Su, Hongliang Wu, Bing Mu, Mandula Bao, Shou Luo, Chuanduo Zhao, Qian Liu, Xishan Wang, Zhixiang Zhou and Haitao Zhou

    Citation: World Journal of Surgical Oncology 2020 18:159

    Content type: Research

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  4. The purpose of this study was to compare clinicopathological features of patients with non-schistosomal and schistosomal colorectal cancer to explore the effect of schistosomiasis on colorectal cancer (CRC) pa...

    Authors: Weixia Wang, Kui Lu, Limei Wang, Hongyan Jing, Weiyu Pan, Sinian Huang, Yanchao Xu, Dacheng Bu, Meihong Cheng, Jing Liu, Jican Liu, Weidong Shen, Yingyi Zhang, Junxia Yao and Ting Zhu

    Citation: World Journal of Surgical Oncology 2020 18:149

    Content type: Research

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  5. The GOD VISION wireless smart glass-shaped monitor (INBYTE) was used in the treatment of an elderly patient with mixed breathing disorder undergoing transanal minimally invasive surgery (TAMIS) for low rectal ...

    Authors: Nobuhisa Matsuhashi, Yoshinori Iwata, Mana Kawajiri, Takao Takahashi, Shigeru Kiyama, Shunya Kiriyama, Machi Uehara, Takeharu Imai, Hisashi Imai, Yoshihiro Tanaka, Naoki Okumura and Kazuhiro Yoshida

    Citation: World Journal of Surgical Oncology 2020 18:141

    Content type: Case report

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  6. Colorectal cancer (CRC) is an important current problem concerning public health due to its high incidence and mortality. Advances in molecular and cellular knowledge and the detection of new disease biomarker...

    Authors: Ana Nogués, Eunate Gallardo-Vara, Mª. Paz Zafra, Paloma Mate, Jose Luis Marijuan, Alfredo Alonso, Luisa Mª. Botella and Mª. Isabel Prieto

    Citation: World Journal of Surgical Oncology 2020 18:99

    Content type: Research

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  7. Whether primary tumor location of colorectal cancer (CRC) affects survival of patients after resection of liver metastases remains controversial. This study was conducted to investigate the differences in clin...

    Authors: Yuanping Zhang, Yongjin Wang, Yichuan Yuan, Jiliang Qiu, Yuxiong Qiu, Wei He, Yun Zheng, Zhiqiang Wang, Yangkui Gu, Zhenhai Lu, Gong Chen, Peirong Ding, Xiaojun Wu, Zhizhong Pan, Desen Wan, Yuhong Li…

    Citation: World Journal of Surgical Oncology 2020 18:98

    Content type: Research

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  8. Mini-invasive colorectal cancer surgery was adopted widely in recent years. This meta-analysis aimed to compare hand-assisted laparoscopic surgery (HALS) with open right hemicolectomy (OS) for malignant disease.

    Authors: Mohamed Ali Chaouch, Mohamed Wejih Dougaz, Meriem Mesbehi, Hichem Jerraya, Ramzi Nouira, Jim S. Khan and Chadli Dziri

    Citation: World Journal of Surgical Oncology 2020 18:91

    Content type: Review

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  9. The incidence of synchronous RCC and colorectal cancer is heterogeneous ranging from 0.03 to 4.85%. Instead, only one case of huge colon carcinoma and renal angiomyolipoma was reported. The treatment of synchr...

    Authors: G. Cochetti, A. Tiezzi, A. Spizzirri, D. Giuliani, J. A. Rossi de Vermandois, G. Maiolino, M. Coccetta, V. Napolitano, F. Pennetti Pennella, S. Francesconi and E. Mearini

    Citation: World Journal of Surgical Oncology 2020 18:86

    Content type: Case report

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  10. The long-term oncological effects of self-expandable metallic stent (SEMS) as a “bridge to surgery” are contradictory, and perineural invasion was supposed to be enhanced by the stenting. In this retrospective...

    Authors: Yinghao Cao, Ming Yang, Lizhao Yan, Shenghe Deng, Junnan Gu, Fuwei Mao, Ke Wu, Li Liu and Kailin Cai

    Citation: World Journal of Surgical Oncology 2020 18:77

    Content type: Research

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  11. RFA is designed to produce localized tumor destruction by heating the tumor and surrounding liver tissue, especially suitable for patients who do not qualify for hepatic resection. Many studies have reported t...

    Authors: Xiao-xiang Fan, Shu-yi Lv, Mei-wu Zhang, Xiao-yu Dai, Jian-pei Zhao, Da-feng Mao and Yan Zhang

    Citation: World Journal of Surgical Oncology 2020 18:76

    Content type: Research

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  12. It is not clear whether stage II colon and rectal cancer have the same risk factors for recurrence. Thus, the purpose of this study was to identify the risk factors for postoperative recurrence in stage II col...

    Authors: Liming Wang, Yasumitsu Hirano, Toshimasa Ishii, Hiroka Kondo, Kiyoka Hara, Nao Obara and Shigeki Yamaguchi

    Citation: World Journal of Surgical Oncology 2020 18:54

    Content type: Research

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  13. Colorectal cancer (CRC) is one of the most common malignancies of the digestive system, which causes severe financial burden worldwide. However, the specific mechanisms involved in CRC are still unclear.

    Authors: Jianxin Li, Yinchun Wang, Xin Wang and Qingqiang Yang

    Citation: World Journal of Surgical Oncology 2020 18:50

    Content type: Research

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  14. Surgical site infections (SSIs) are a major postoperative complication after colorectal surgery. Current study aims to evaluate prophylactic function of oral antibiotic (OA) intake in combination with mechanic...

    Authors: Purun Lei, Ying Ruan, Xiaofeng Yang, Juekun Wu, Yujie Hou, Hongbo Wei and Tufeng Chen

    Citation: World Journal of Surgical Oncology 2020 18:35

    Content type: Research

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  16. Even with the augmentative application of anal-preservation surgery in low rectal cancer, the role and indications of laparoscopic intersphincteric resection (Lap ISR) are still under debate, especially for T3...

    Authors: Wangsheng Xue, Shuang Wang, Zeyun Zhao, Yongbo Li, An Shang, Donglin Li, Jianzheng Yang, Tiejun Wang and Min Wang

    Citation: World Journal of Surgical Oncology 2020 18:26

    Content type: Research

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  17. The proximal humerus is one of the most common sites of primary or metastatic malignant tumors. Reconstruction of the shoulder after tumor resection is controversial and challenging. When intra-articular resec...

    Authors: Weitao Yao, Qiqing Cai, Jiaqiang Wang and Jingyu Hou

    Citation: World Journal of Surgical Oncology 2020 18:23

    Content type: Research

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  18. Fecal incontinence frequently occurs after total mesorectal excision for rectal cancer. This prospective study analyzed predictive factors and the impact of pelvic intraoperative neuromonitoring at different f...

    Authors: Daniel W. Kauff, Yvonne D. S. Roth, Rika S. Bettzieche and Werner Kneist

    Citation: World Journal of Surgical Oncology 2020 18:12

    Content type: Research

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  19. To describe the pathological distribution, imaging manifestations, and surgical managements and prognosis of large adrenal tumors (LATs) ≥ 5 cm

    Authors: Zongzong Zhang, Lina Wang, Jing Chen, Xiunan Li, Dikuan Liu, Tianyu Cao, Xuehan Yang, Hongwei Huang, Xuejian Wang, Xishuang Song, Deyong Yang and Jianbo Wang

    Citation: World Journal of Surgical Oncology 2019 17:220

    Content type: Research

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  20. Glove single-port laparoscopy-assisted transanal total mesorectal excision (TaTME) has been successfully carried out in our medical center. The purpose of this study is to evaluate the feasibility of this emer...

    Authors: Wanglin Li, Boye Dong, Baifu Peng, Jiabao Lu, Zixin Wu, Guanwei Li and Jie Cao

    Citation: World Journal of Surgical Oncology 2019 17:202

    Content type: Technical innovations

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  21. In recent years, laparoscopic surgery has been widely used for rectal cancer. In laparoscopic rectal surgery, a double-stapling technique (DST) anastomosis using a stapling device is considered a relatively di...

    Authors: Masahiro Fukada, Nobuhisa Matsuhashi, Takao Takahashi, Hisashi Imai, Yoshihiro Tanaka, Kazuya Yamaguchi and Kazuhiro Yoshida

    Citation: World Journal of Surgical Oncology 2019 17:178

    Content type: Research

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  22. The recurrence after curative surgery of the rectal adenocarcinoma is a serious complication, considered as a failure of the therapeutic strategy. The aim of this study was to identify the different prognostic...

    Authors: Waad Farhat, Mohamed Azzaza, Abdelkader Mizouni, Houssem Ammar, Mahdi ben Ltaifa, Sami Lagha, Mohamed Kahloul, Rahul Gupta, Mohamed Ben Mabrouk and Ali Ben Ali

    Citation: World Journal of Surgical Oncology 2019 17:173

    Content type: Research

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  23. To explore the relationship between FABP4 and FABP6 expression and the pathogenesis of colorectal cancer (CRC) and their potential as biomarkers in the diagnosis of CRC.

    Authors: Yaqin Zhang, Xiaotong Zhao, Lili Deng, Xueting Li, Ganbiao Wang, Yongxing Li and Mingwei Chen

    Citation: World Journal of Surgical Oncology 2019 17:171

    Content type: Research

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  24. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Rectal locations are very rare, and minimally invasive surgery is a good choice for the treatment o...

    Authors: Wang Shizhuo, Liuyuan, Ni Sha, Chen Xueting, Wang He, Luan Nannan and Ma Xiaoxin

    Citation: World Journal of Surgical Oncology 2019 17:164

    Content type: Case report

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  25. The free flap transfer of a latissimus dorsi flap (LDF) for the closure of sacral wound defects after pelvic exenteration and radiation therapy offers a successful tool of the plastic surgeon. This case report...

    Authors: Jan Matschke, Rafael Armbruster, Christian Reeps, Jürgen Weitz and Adrian Dragu

    Citation: World Journal of Surgical Oncology 2019 17:154

    Content type: Case report

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  26. Post-treatment management is essential for improving the health and quality of life of colorectal cancer (CRC) survivors. The number of cancer survivors is continually increasing, which is causing a correspond...

    Authors: Ameera Balhareth, Mohammed Yousef Aldossary and Deborah McNamara

    Citation: World Journal of Surgical Oncology 2019 17:153

    Content type: Review

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  27. Cancer metastasis from colon cancer to an anal fistula is very rare. We herein reported a rare case in which local excision was performed for metastatic anal fistula cancer originating from rectal cancer.

    Authors: Takuto Ikeda, Atsushi Nanashima, Akiko Ichihara, Eiji Kitamura, Kenzo Nagatomo and Hiroyuki Tanaka

    Citation: World Journal of Surgical Oncology 2019 17:149

    Content type: Case report

    Published on:

  28. This study aims to present the feasibility of the open approach of hemilevator excision (HLE) as a promising alternative of the laparoscopic and/or robotic ones for the treatment of low rectal cancer extending...

    Authors: Theodoros Mariolis-Sapsakos, Giannos Psathas, Taxiarchis Konstantinos Nikolouzakis, Konstantinos Laschos, Charikleia Triantopoulou, Gerasimos Bonatsos and John Tsiaoussis

    Citation: World Journal of Surgical Oncology 2019 17:131

    Content type: Technical innovations

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