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  1. Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problem...

    Authors: Raphael Romano Bruno, Bernhard Wernly, Malte Kelm, Ariane Boumendil, Alessandro Morandi, Finn H. Andersen, Antonio Artigas, Stefano Finazzi, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Michael Lichtenauer, Johanna M. Muessig, Brian Marsh, Rui Moreno, Sandra Oeyen…

    Citation: BMC Geriatrics 2021 21:576

    Content type: Research

    Published on:

  2. Pre-treatment evaluation for sarcopenia is recommended in cancer patients. New screening tests that are less time-consuming and can identify patients who will potentially benefit from geriatric assessment are ...

    Authors: Cagatay Cavusoglu, Gozde Tahtaci, Rana Tuna Dogrul, Ibrahim Ileri, Funda Yildirim, Burcu Candemir, Muhammet Cemal Kizilarslanoglu, Aytug Uner and Berna Goker

    Citation: BMC Geriatrics 2021 21:574

    Content type: Research

    Published on:

  3. Cerebellar degeneration is a rare and severe presentation of primary Sjögren syndrome. There are few case reports of cerebellar degeneration associated with different autoimmune diseases, especially with syste...

    Authors: Seow Lin Chuah, Ahmad Tirmizi Jobli, Sharifah Aishah Wan and Cheng Lay Teh

    Citation: Journal of Medical Case Reports 2021 15:526

    Content type: Case report

    Published on:

  4. Uveal effusion syndrome is a rare disease characterized by exudative detachments of the choroid, ciliary body, and retina. Various surgical procedures and nonsurgical strategies have been described to treat uv...

    Authors: Li Song, Fangtian Dong and Changxian Yi

    Citation: Journal of Medical Case Reports 2021 15:515

    Content type: Case report

    Published on:

  5. The Dementia Knowledge Assessment Scale (DKAS) is a reliable and valid measurement of dementia knowledge for diverse allied health professionals but its traditional Chinese version has not been formally valida...

    Authors: Huei-Chuan Sung, Hsin-Feng Su, Hsiu-Mei Wang, Malcolm Koo and Raymond Y. Lo

    Citation: BMC Psychiatry 2021 21:515

    Content type: Research

    Published on:

  6. Evidence on determinants of prices for orphan medicines is scarce and not available for Italy. The aim of this paper is to provide an evidence on variables affecting the annual treatment cost of orphan drugs i...

    Authors: Claudio Jommi, Elisabetta Listorti, Federico Villa, Simone Ghislandi, Armando Genazzani, Agnese Cangini and Francesco Trotta

    Citation: Orphanet Journal of Rare Diseases 2021 16:439

    Content type: Research

    Published on:

  7. The objective of this study was to describe clinical manifestations and events of patients with mucopolysaccharidosis (MPS) VI in Turkey who are treated with galsulfase enzyme replacement therapy (ERT). Clinic...

    Authors: Aslı İnci, İlyas Okur, Leyla Tümer, Gürsel Biberoğlu, Murat Öktem and Fatih Ezgü

    Citation: Orphanet Journal of Rare Diseases 2021 16:438

    Content type: Research

    Published on:

  8. Wilson disease (WD) is a rare disease wherein copper accumulates in tissues, leading to hepatic degeneration, neurological impairments, and psychiatric symptoms. This study aimed to characterize the patient ex...

    Authors: Stella Karantzoulis, Karli Heuer, Nicole Sparling and Megan Teynor

    Citation: Orphanet Journal of Rare Diseases 2021 16:437

    Content type: Research

    Published on:

  9. The albumin–bilirubin (ALBI) grade has been validated as a significant prognostic predictor for hepatocellular carcinoma (HCC). However, there is little information about the ALBI grade in patients with non-B ...

    Authors: Yu-Chieh Tsai, Fai-Meng Sou, Yueh-Wei Liu, Yi-Ju Wu, Chee-Chien Yong, Ding-Wei Chen, Pao-Yuan Huang, Wei-Ru Cho, Ching-Hui Chuang, Chang-Chun Hsiao, Tsung-Hui Hu and Ming-Chao Tsai

    Citation: BMC Gastroenterology 2021 21:386

    Content type: Research

    Published on:

  12. Rhodopsin (RHO) is the most well-known genetic cause of autosomal dominant retinitis pigmentosa (adRP). This study aimed to investigate the genetic cause of a large Chinese adRP family and assess the pathogeni...

    Authors: Yue Wang, Xi Chen, Xiang Gao, Andi Zhao, Chen Zhao and Xuejuan Chen

    Citation: BMC Ophthalmology 2021 21:371

    Content type: Research

    Published on:

  13. To describe the long-term hemodialysis arteriovenous fistula (AVF) patency, incidence of AVF use, incidence and nature of AVF complications and surgery in patients after kidney transplantation.

    Authors: Barbara Vajdič Trampuž, Miha Arnol, Jakob Gubenšek, Rafael Ponikvar and Jadranka Buturović Ponikvar

    Citation: BMC Nephrology 2021 22:344

    Content type: Research

    Published on:

  14. Circular RNAs (circRNAs) are a class of non-coding RNA that play critical roles in the development and pathogenesis of various cancers. The circRNA circGSK3B (hsa_circ_0003763) has been shown to enhance cell p...

    Authors: Xianxiong Ma, Hengyu Chen, Lei Li, Feng Yang, Chuanqing Wu and Kaixiong Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:330

    Content type: Research

    Published on:

  15. The combination of bevacizumab and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) could prolong progression-free survival (PFS) in patients with EGFR-mutant advanced non-small-cell lung c...

    Authors: Yongchang Zhang, Liang Zeng, Xiangyu Zhang, Yizhi Li, Lingli Liu, Qinqin Xu, Haiyan Yang, Wenjuan Jiang, Analyn Lizaso, Luting Qiu, Ting Hou, Jun Liu, Ling Peng and Nong Yang

    Citation: BMC Medicine 2021 19:245

    Content type: Research article

    Published on:

  16. Chorioamnionitis (CHORIO) is a principal risk factor for preterm birth and is the most common pathological abnormality found in the placentae of preterm infants. CHORIO has a multitude of effects on the matern...

    Authors: Yuma Kitase, Eric M. Chin, Sindhu Ramachandra, Christopher Burkhardt, Nethra K. Madurai, Colleen Lenz, Alexander H. Hoon Jr, Shenandoah Robinson and Lauren L. Jantzie

    Citation: Journal of Neuroinflammation 2021 18:242

    Content type: Research

    Published on:

  17. Cognitive impairment in the late stage of traumatic brain injury (TBI) is associated with the NOD-, LRR and pyrin domain-containing protein 3 (NLRP3) inflammasome, which plays an important role in neuroinflamm...

    Authors: Si-Wei Tan, Yan Zhao, Ping Li, Ya-Lei Ning, Zhi-Zhong Huang, Nan Yang, Dong Liu and Yuan-Guo Zhou

    Citation: Journal of Neuroinflammation 2021 18:241

    Content type: Research

    Published on:

  18. Lysophosphatidic acid receptors (LPARs) are G-protein-coupled receptors involved in many physiological functions in the central nervous system. However, the role of the LPARs in multiple sclerosis (MS) has not...

    Authors: Jong Hee Choi, Jinhee Oh, Min Jung Lee, Hyunsu Bae, Seong-Gyu Ko, Seung-Yeol Nah and Ik-Hyun Cho

    Citation: Journal of Neuroinflammation 2021 18:240

    Content type: Research

    Published on:

  19. Multiple studies have revealed that repeated or long-term exposure to ketamine causes neurodegeneration and cognitive dysfunction. Pyroptosis is an inflammatory form of programmed cell death that has been link...

    Authors: Zhiheng Zhang, Hui Bai, Xiangying Ma, Meilun Shen, Rouqian Li, Di Qiu, Siyao Li and Li Gao

    Citation: Journal of Neuroinflammation 2021 18:239

    Content type: Research

    Published on:

  20. With the dramatic increase in the pipeline for new sickle cell disease (SCD) therapies in recent years, the time is ripe to ensure a robust body of evidence is available for decision making by regulators, paye...

    Authors: Ellen Tambor, Matoya Robinson, Lewis Hsu, Hsing-Yuan Chang and Jennifer Al Naber

    Citation: BMC Medical Research Methodology 2021 21:219

    Content type: Research article

    Published on:

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