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  1. Triple negative breast cancers (TNBC) are a more aggressive subset of breast cancer. A better understanding of its biology could allow the rational development of targeted therapies.

    Authors: William Jacot, Caroline Mollevi, Frédéric Fina, Evelyne Lopez-Crapez, Pierre-Marie Martin, Pierre-Emmanuel Colombo, Frédéric Bibeau, Gilles Romieu and Pierre-Jean Lamy

    Citation: BMC Cancer 2015 15:986

    Content type: Research article

    Published on:

  2. Cancer-cachexia state frequently induces both fat and protein wasting, leading to death. In this way, the knowledge of the mechanism of drugs and their side effects can be a new feature to treat and to have su...

    Authors: André G. Oliveira and Maria Cristina C. Gomes-Marcondes

    Citation: BMC Cancer 2016 16:418

    Content type: Research article

    Published on:

  3. Identification of BRCA mutations in breast cancer (BC) patients influences treatment and survival and may be of importance for their relatives. Testing is often restricted to women fulfilling high-risk criteria. ...

    Authors: Eli Marie Grindedal, Cecilie Heramb, Inga Karsrud, Sarah Louise Ariansen, Lovise Mæhle, Dag Erik Undlien, Jan Norum and Ellen Schlichting

    Citation: BMC Cancer 2017 17:438

    Content type: Research article

    Published on:

  4. Metastases account for 90% of all cancer-related deaths, becoming a therapeutic problem. Approximately 50% of all uveal melanoma (UM) patients will develop metastases, mainly in the liver. Post-mortem analyses of...

    Authors: Nyasia M. Jones, Hua Yang, Qing Zhang, Vanessa M. Morales-Tirado and Hans E. Grossniklaus

    Citation: BMC Cancer 2019 19:484

    Content type: Research article

    Published on:

  5. Germline mutations in PALB2 have been identified in approximately 1% of familial breast cancer (BC) in several populations. Nevertheless its contribution in the South-American population is unknown. The goal of t...

    Authors: Yessica Leyton, Patricio Gonzalez-Hormazabal, Rafael Blanco, Teresa Bravo, Ricardo Fernandez-Ramires, Sebastian Morales, Natalia Landeros, Jose M Reyes, Octavio Peralta, Julio C Tapia, Fernando Gomez, Enrique Waugh, Gladys Ibañez, Janara Pakomio, Gilberto Grau and Lilian Jara

    Citation: BMC Cancer 2015 15:30

    Content type: Research article

    Published on:

  7. Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking ...

    Authors: Loredana Radoï, Gwenn Menvielle, Diane Cyr, Bénédicte Lapôtre-Ledoux, Isabelle Stücker and Danièle Luce

    Citation: BMC Cancer 2015 15:827

    Content type: Research article

    Published on:

  8. Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis. Posttranslational regulation of HIF-1α is dependent on Prolyl hydroxylase (PHD 1–3) and Factor Inhibiting HIF (FI...

    Authors: Sarah L. Miles, Adam P. Fischer, Sandeep J. Joshi and Richard M. Niles

    Citation: BMC Cancer 2015 15:867

    Content type: Research article

    Published on:

  9. Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of th...

    Authors: Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng and You-Guang Lu

    Citation: BMC Cancer 2018 18:436

    Content type: Research article

    Published on:

  10. Tamoxifen is a frontline therapy for estrogen receptor (ER)-positive breast cancer in premenopausal women. However, many patients develop resistance to tamoxifen, and the mechanism underlying tamoxifen resista...

    Authors: Wei Li, Ling Xu, Xiaofang Che, Haizhou Li, Ye Zhang, Na Song, Ti Wen, Kezuo Hou, Yi Yang, Lu Zhou, Xing Xin, Lu Xu, Xue Zeng, Sha Shi, Yunpeng Liu, Xiujuan Qu…

    Citation: BMC Cancer 2018 18:507

    Content type: Research article

    Published on:

  11. Genome-wide association studies (GWAS) have identified more than 40 colorectal cancer susceptibility loci, but only a small fraction of heritability was explained. To account for missing heritability, we inves...

    Authors: Nan Song, Jeeyoo Lee, Sooyoung Cho, Jeongseon Kim, Jae Hwan Oh and Aesun Shin

    Citation: BMC Cancer 2019 19:1231

    Content type: Research article

    Published on:

  12. To investigate the incidence of non-cancer mortalities and prognostic factors associated with competitive causes of death in a homogeneous cohort of patients with locally advanced head and neck cancer treated ...

    Authors: I. Zapata, M. Alvarez, R. Hidalgo, B. Pajares, M. J. Garcia-Anaya, M. D. Toledo, J. M. Trigo, Y. Lupiañez-Perez, J. A. Medina and J. Jaime Gomez-Millan

    Citation: BMC Cancer 2019 19:1241

    Content type: Research article

    Published on:

  13. The best strategy for surveillance testing in stage II and III colon cancer patients following curative treatment is unknown. Previous randomized controlled trials have suffered from design limitations and yie...

    Authors: Robert B. Hines, Md Jibanul Haque Jiban, Adrian V. Specogna, Priya Vishnubhotla, Eunkyung Lee and Shunpu Zhang

    Citation: BMC Cancer 2019 19:418

    Content type: Research article

    Published on:

  14. TP53 mutations occur in only about 3% of primary and 10–20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative mechanisms may contribute to functionally impairing the p53 pa...

    Authors: Lixian Oh, Pierre Hainaut, Sandrine Blanchet and Hany Ariffin

    Citation: BMC Cancer 2020 20:110

    Content type: Research article

    Published on:

  15. Antimicrobial peptides (AMPs) play important roles in the innate immune system of all life forms and recently have been characterized as multifunctional peptides that have a variety of biological roles such as...

    Authors: Kengo Kuroda, Tomokazu Fukuda, Marija Krstic-Demonacos, Constantinos Demonacos, Kazuhiko Okumura, Hiroshi Isogai, Miwa Hayashi, Kazuki Saito and Emiko Isogai

    Citation: BMC Cancer 2017 17:33

    Content type: Research article

    Published on:

  16. To investigate the association between pre-diagnostic colonoscopy and colorectal cancer mortality in South Australia.

    Authors: Ming Li, Ian Olver, Dorothy Keefe, Carol Holden, Dan Worthley, Timothy Price, Christos Karapetis, Caroline Miller, Kate Powell, Dianne Buranyi-Trevarton, Kellie Fusco and David Roder

    Citation: BMC Cancer 2019 19:856

    Content type: Research article

    Published on:

  17. Breast cancer survivors have an elevated risk of cognitive impairment compared to age-matched women without cancer. Causes of this impairment are complex, including both treatment and psychological factors. Mi...

    Authors: Gabriella Cifu, Melinda C. Power, Sarah Shomstein and Hannah Arem

    Citation: BMC Cancer 2018 18:1163

    Content type: Research article

    Published on:

  18. Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality and metastatic potential, there is a lack of effective therapies and a low survival rate for this disease. This PDAC scenario urges ...

    Authors: Palloma Porto Almeida, Cristina Padre Cardoso and Leandro Martins de Freitas

    Citation: BMC Cancer 2020 20:82

    Content type: Software

    Published on:

  19. The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in patients with breast cancer remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopatho...

    Authors: Daqing Jiang, Zhaohua Gao, Zhengang Cai, Meixian Wang and Jianjun He

    Citation: BMC Cancer 2015 15:727

    Content type: Research article

    Published on:

  20. Pancreatic cancer remains one of the most difficult cancers to treat with the poorest prognosis. The key to improving survival rates in this disease is early detection and monitoring of disseminated and residu...

    Authors: Julie Earl, Sandra Garcia-Nieto, Jose Carlos Martinez-Avila, José Montans, Alfonso Sanjuanbenito, Mercedes Rodríguez-Garrote, Eduardo Lisa, Elena Mendía, Eduardo Lobo, Núria Malats, Alfredo Carrato and Carmen Guillen-Ponce

    Citation: BMC Cancer 2015 15:797

    Content type: Research article

    Published on:

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